Emerging Trends in Erectile Dysfunction Treatment: An Overview of Recent Advances in Medication

Virtually every man has experienced erectile dysfunction, even if his sex drive has not weakened. This is a sensitive, even taboo, topic that men hesitate to discuss.

Yes, almost every man knows about Viagra pills, which have become a classic in overcoming erectile dysfunction (ED). But science does not stand still. Every day there are more and more studies, developments, and innovations in the field of ED treatment.

In this article, we will introduce you to new methods and trends in the treatment of erectile dysfunction that could potentially be a good alternative to the well-known little blue pill. Let's find out what sexual health professionals have to offer in the near future when we seek their help.

A brief history of ED treatment

A brief history of ED treatment

In almost every culture, you can find references to miracle remedies (plant extracts, talismans made from animal genitalia, etc.) that improve sexual power in men. Such references are found in ancient Chinese texts, Egyptian papyri, and other written sources.

In the 20th century, when the role of testosterone in stimulating sexual function was recognized, there appeared drugs that contained this hormone or stimulated its production in the body. However, the biggest breakthrough came in 1998, when Viagra became the first oral medication approved to treat ED.

Although drugs like Viagra are very effective, the prevalence of ED increases every year for the following reasons, among others:

●       Lifestyle diseases - diabetes, obesity, hyperlipidemia, atherosclerosis, and others.

●       Taking medications that have the side effect of ED and/or decreased libido - selective serotonin reuptake inhibitors, beta-blockers, and others.

Therefore, the search for safer treatment options continues with evidence-based medicine and clinical efficacy results. New treatment options are expected to help men, suffering from ED of various etiologies, and their partners maintain a satisfactory sex life, as well.

Popular ED medications over the past 30 years

Original medicine

Molecular formula

Active substance

Viagra

C22H30N6O4S

Sildenafil

Cialis

C22H19N3O4

Tadalafil

Stendra

C23H26ClN7O3

Avanafil

Levitra

C23H32N6O4S

Vardenafil

All of the above drugs are classified as PDE5 inhibitors. Their mechanism of action is associated with the dilation of large and small blood vessels of the penis. Vascular dilation improves blood flow, which leads to an erection when sexually aroused.

The new generation of oral ED drugs

Unfortunately, some men do not respond to traditional ED treatments or are not 100% satisfied with them. The good thing is that new drugs are being developed in addition to the already-known and popular PDE5 inhibitors. They have the same mechanism of action, but there are some differences in pharmaceutical properties.

Prominent representatives of such drugs are as follows.

Brand name

Generic name

Formula

Zydena

Udenafil

C25H36N6O4S

Mvix

Mirodenafil

C26H37N5O5S

Helleva

Lodenafil Carbonate

C23H32N6O5S

Zydena (Udenafil)

Udenafil is a new-generation ED drug with an excellent balance between efficacy and tolerability profile. It has passed all clinical trials in Korea and is already marketed there, and in several other countries. At this time, Udenafil (Zydena) is not approved by the FDA and is not sold in the United States and most other countries around the world.

Here is what we already know about this drug and its features:

●       It is the first ED medication developed in Korea.

●       It is produced as oral tablets with dosages of 50 mg, 75 mg, 100 mg, and 200 mg.

●       The action duration of one tablet is 8-12 hours.

●       The tablet should be taken 30 minutes before sexual activity.

●       The maximum recommended dosing frequency is once a day.

●       During clinical trials, no side effects, such as back pain and myalgia, have been reported. This is attributed to the fact that Zydena does not inhibit PDE11, unlike most other ED medications.

●       Small doses of alcohol do not affect the effects of Udenafil, although they may cause or exacerbate some adverse reactions.

●       The most common side effects are headache and hot flashes, as with Cialis, Viagra, Levitra, and Stendra.

Mvix (Mirodenafil)

Mirodenafil is another second-generation PDE5I available in South Korea. At this time, Mvix (Mirodenafil) is not approved by the FDA and is not sold in the U.S. or most other countries in the world.

Here is what we already know about this drug and its features:

●       It is manufactured as 50 mg and 100 mg oral tablets and 50 mg oral dissolving film.

●       It is taken about 30-60 minutes before sexual activity, no more than once a day.

●       The half-life of the active ingredient Mirodenafil is 2.5 hours.

●       The maximum recommended dosing frequency is once a day.

●       Small doses of alcohol do not affect the effect of Udenafil, although they may cause or increase some adverse reactions.

Mvix has been shown to be 10 times more selective against PDE5 than Viagra is. This means that the new drug effectively dilates the blood vessel walls of the penis and has less effect on other organs and body systems.

Mvix has less effect on other types of phosphodiesterase enzymes located in soft tissues throughout the body. This reduces the risk of many of the side effects (e.g., vision problems) that occur with Viagra.

Helleva (Lodenafil Carbonate)

Helleva is a prodrug. In other words, it is inactive in its original form, but once ingested, it turns into its active derivatives.

Helleva is part of a new generation of PDE5 inhibitors. The drug has shown safety and efficacy in clinical trials conducted in Brazil. The FDA has not yet approved the new drug and it is not marketed in most countries of the world.

Here is what we already know about this drug and its features:

●       The formula is developed in Brazil.

●       It is produced in the form of 80 mg oral tablets.

●       The tablet is taken about 60 minutes before sexual activity.

●       The maximum recommended dosing frequency is once a day.

●       The half-life of the active ingredient Lodenafil is 2.4 hours.

●     Helleva, Cialis, Viagra, Levitra, and Stendra cause such side effects, as headache, dyspepsia, and hot flashes, with about equal frequency.

Experimental treatment options

Experimental treatment options

Because of the huge demand in the ED drug market, research is constantly ongoing to develop new treatment approaches. These treatment options are considered experimental, not yet used in medical practice, but they are already being tested in research facilities.

Stem cell therapy is a potentially very interesting treatment option for ED. It has been suggested that it could be useful in treating all or part of erectile dysfunction.

The new treatment could repair blood vessels that have become blocked or brittle due to aging or lifestyle diseases. Stem cell therapy can reverse cavernous nerve damage, such as that caused by type 2 diabetes.

Plasma therapy (platelet-rich plasma)

Platelets are blood cells that play an important role in wound healing and regenerative processes. They help form clots to stop bleeding and can also support cell growth.

Plasma therapy is an innovative treatment method that uses the patient's own enriched plasma. It is based on the ability of the human body's natural healing powers to regenerate its tissues. Plasma therapy has shown good results in restoring blood vessels and nerves in the penis and pelvic organs.

It should be noted that the experimental studies involved animals and a limited number of humans. The results were partially successful. Scientists emphasize that more research is needed before it will be possible to draw clear conclusions about the treatment effectiveness.

New drugs vs. Cialis, Viagra, Levitra or Stendra

New drugs vs. Cialis, Viagra, Levitra or Stendra

The topic of the effectiveness of different types of ED medications is important. Numerous scientific studies have been conducted to clarify this issue. When comparing Cialis, Viagra, Levitra, or Stendra, there is no difference in effectiveness. Based on this conclusion, we should hardly expect Zydena (Udenafil), Mvix (Mirodenafil), or Helleva (Lodenafil Carbonate) to be more effective than previously developed drugs.

Nevertheless, next-generation PDE5 inhibitors may offer additional benefits in treating erection problems. This is primarily because the new drugs act more selectively, potentially reducing the risks of side effects.

By examining pharmacokinetic properties, we can see that the new ED drugs do not act any faster than previously discovered drugs do. It can also be seen that nothing has been able to beat Cialis, which lasts 36 hours, in terms of the action duration.

We can expect stem cell therapy or plasma therapy to revolutionize ED even more than Viagra did in 1998. But any method of treatment will have certain limitations and may not be suitable for every man, nor can it guarantee 100% results.

Conclusion

In most men, erectile dysfunction can be successfully treated with oral PDE5Is. This is true for the dominant brands, as well as new and not yet very popular ED medications.

They all work well regardless of the etiology or severity of the disease. Some PDE5Is can reduce the risks of side effects, allowing more men to improve their sex lives.

Innovative treatments for ED are not yet approved by such regulatory bodies as the FDA. They are promising but require more research and a comprehensive safety assessment.

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